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April 15, 1992

Thompson & Thompson Genetics in Medicine

Author Affiliations

East Carolina University School of Medicine Greenville, NC

JAMA. 1992;267(15):2115. doi:10.1001/jama.1992.03480150121052

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This latest edition of Thompson and Thompson's Genetics in Medicine has been updated by more recent information and is larger than the fourth edition, which was published in 1986. This 1991 volume has the advantage of being produced by three very knowledgeable and literate authors with input by multiple acknowledged leaders in the field of genetics. In this instance, "more is better."

The areas of expansion include additions to multiple chapters such as single-gene inheritance, with discussions of fragile X syndrome, phenotypic expressions of various disorders, mitochondrial genetics, genetic imprinting, and uniparental disomies. The authors have added superb coverage of the newer methods and tools used in gene linkage and mapping. Further, there is considerably more information on the clinical aspects of chromosome abnormalities and on molecular and biochemical genetic disorders. The sections on cancer genetics and gene therapy are also new in this volume. Previous brief, incomplete discussions of