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May 20, 1992

Body Compositional Changes in Response to Testosterone-Reply

Author Affiliations

University of Rochester (NY) School of Medicine and Dentistry

JAMA. 1992;267(19):2606. doi:10.1001/jama.1992.03480190048028

In Reply.  —We wish to respond to the points raised by Coodley et al in their comments on our article.1 We did not state or imply that anabolic steroids are a safe, reasonable approach for normal healthy men to increase muscle mass.The normal volunteers reported in JAMA were monitored closely. As reported earlier,2 there were no changes in serum cholesterol or serum triglyceride levels, or liver function tests. Serum creatinine and creatine kinase levels, and hematocrit rose significantly while plasma follicle-stimulating hormone, luteinizing hormone, and thyroxine levels fell. Subjects were interviewed and evaluated monthly for side effects. Acne and weight gain were the only changes. Not reported previously were the facts that blood pressure, mood, and muscle strength as measured with a hand dynamometer did not change significantly and consistently in this short-term study.The normal men were studied concurrently with adult ambulatory men with myotonic dystrophy