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February 28, 1996

Heart Failure: Cardiac Function and Dysfunction

Author Affiliations

Albert Einstein College of Medicine Flushing Medical Center Flushing, NY

JAMA. 1996;275(8):644. doi:10.1001/jama.1996.03530320068040

During the last decade, significant advances have been made in our understanding of the alterations taking place at the molecular and cellular level and in gene expression of cardiovascular disease.1,2 In the preface, Braunwald and Colucci point out that advances in diagnosis, treatment, and prevention of such disorders have made possible a 26% decrease in the death rate from 1981 to 1991, while 400000 new cases of heart failure are diagnosed each year. The magnitude of this problem does not seem to be affected by common and traditional approaches. Heart Failure, the second volume of the Atlas of Heart Diseases, offers better insight into the basic mechanisms of normal cardiac function, cardiac dysfunction, and treatment of heart failure, by illustrating contemporary new advances.

The first of 13 chapters reviews the molecular and cellular basis of contraction, and the second chapter reveals the myocardial mechanisms and neurohumoral regulation of the