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March 22, 1985

Isolation of Lymphadenopathy-Associated Virus (LAV) and Detection of LAV Antibodies From US Patients With AIDS

Author Affiliations

From the Viral Oncology Unit, Pasteur Institute, Paris (Drs Barré-Sinoussi, Montagnier, and Chermann and Ms Rey); the Laboratory of Virology, Claude Bernard Hospital, Paris (Dr Brun-Vezinet and Ms Rouzioux); and the Department of Medicine, Beth Israel Medical Center, The Mount Sinai School of Medicine of the City University of New York (Drs Mathur-Wagh, Yancovitz, and Mildvan).

JAMA. 1985;253(12):1737-1739. doi:10.1001/jama.1985.03350360063019

A human retrovirus was isolated from the peripheral blood of three American patients newly diagnosed with the acquired immunodeficiency syndrome (AIDS). In each case the major core viral protein (p25) was shown to be antigenically identical to that of the prototype lymphadenopathyassociated virus (LAV). Two of the viral isolates were derived from intravenous narcotics abusers, the first demonstration of LAV isolation from this risk group. Antibody to LAV was detected by an IgG enzyme-linked immunosorbent assay in the serum samples of these and 14 additional American patients with AIDS and in none of 12 hospital worker controls. These findings provide support for the etiologic association of LAV and AIDS.

(JAMA 1985;253:1737-1739)