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April 5, 1985

The Diagnosis of Multiple Sclerosis

Author Affiliations

Northwestern University Medical School Chicago

JAMA. 1985;253(13):1937. doi:10.1001/jama.1985.03350370133041

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This 253-page book contributed to by 33 authors is packed with information. It is the product of a workshop sponsored by the Department of Neurology, Boston University.

At times, clear-cut neurological symptoms and signs disseminated in time and space may not be available to the clinician for the diagnosis of multiple sclerosis. The recent advances in medical technology provide help in these vague cases. The authors give a timely review of electrophysiological tests, cerebrospinal fluid electrophoresis and analysis, computer tomography, and nuclear magnetic resonance.

The chapters on clinical neurology, neuropsychology, neuro-ophthalmology and neuro-urology provide insight and explanation of some of the unusual symptoms and signs presented by multiple sclerosis. The incorporation of these laboratory procedures and clinical data necessitates the revision of the existing diagnostic criteria for multiple sclerosis. The proposed new diagnostic guidelines are succinct and easy to apply. I predict the guidelines will be widely used in the