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May 10, 1985

Mutations in Man

Author Affiliations

Northwestern University Medical Center Chicago

JAMA. 1985;253(18):2759. doi:10.1001/jama.1985.03350420173041

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Physicians seem deluged with claims of mutagenicity, not only for drugs but for ubiquitous environmental agents. This volume, edited by Günter Obe from Berlin, does not attempt to provide clinical answers. It does, however, provide background data that can help physicians appreciate why simple answers to queries about mutagenicity may prove unrealistic.

The 13 chapters are individually scholarly; however, the topics chosen for inclusion seem selective. Some represent background, whereas others address specific research topics. Among background topics is a review of the organization of the genome, by M. J. Evans. The principles of gene mutations are discussed by F. Vogel. Various aspects of human cytogenetics are covered by K. Sperling, I. Hansmann, and A. T. Natarajani. Adducts of DNA and DNA repair systems are reviewed as well. All these chapters may well prove useful to many physicians wishing to update their background in this area.

Other chapters emphasize more