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Article
August 19, 1992

NIH Scientists Retract Published Report

JAMA. 1992;268(7):848-851. doi:10.1001/jama.1992.03490070022009

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Abstract

FRAUDULENT SCIENCE published, detected, admitted, and retracted in the journal in which the paper originally appeared. Matter closed? The answer is no.

Harvard Medical School, Boston, Mass, now has announced that the central figure in the situation, third-year student Mitchell H. Rosner, may not continue his studies there.

In March 1991, the journal Cell published a paper by National Cancer Institute researchers, reporting evidence that early embryonic cell division in the mouse is controlled by a maternal transcription factor regulated by a gene called Oct-3 (Cell. 1991;64:1103-1110). The work had its foundations in earlier studies on the Oct-3 gene that have been independently confirmed (Nature. 1990; 354:686-692).

Cell Report  The Cell paper reported experiments showing that when Oct-3 was neutralized, embryonic DNA synthesis was inhibited and the fertilized embryos never got beyond one-cell division. Conversely, when the blocking agent preventing the Oct-3 transcription factor from operating was removed, cell division

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