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August 19, 1992

Varicella Vaccine Expected to Be Ready by 1993

JAMA. 1992;268(7):851-852. doi:10.1001/jama.1992.03490070029011

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IF PRESENT FINDINGS hold up, US physicians should by early next year have a safe and effective vaccine against varicella.

Trials with production lots of the vaccine are under way. A license application will be submitted to the Food and Drug Administration, Rockville, Md, probably in the next two or three months.

Measles-Mumps-Rubella-Varicella?  Meanwhile, the manufacturer is studying incorporation of the varicella vaccine into the measles-mumps-rubella combination. When this is licensed, investigators say, it should simplify the pediatric immunization schedule.The varicella vaccine is an attenuated live virus agent, cultivated for 31 passages on MRC-5 cells, a human diploid line. To date, more than 9000 children and 2000 adolescents and adults in a number of studies have been immunized with the agent with an overall efficacy greater than 80%.Some 95% of vaccinees have demonstrated protective antibody titers for up to six years. The vaccine is given by subcutaneous injection