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July 5, 1985

Hepatic Vascular Lesions in AIDS

Author Affiliations

Louis Mourier Hospital Colombes, France

JAMA. 1985;254(1):53-54. doi:10.1001/jama.1985.03360010059009

To the Editor.—  In their article entitled "Autopsy Findings in the Acquired Immune Deficiency Syndrome," Dr Welch and associates1 always found hepatic lesions that were sinusoidal dilatations. As the pathogenesis of these lesions is not discussed by the authors, I would like to describe our very similar findings.2We performed systematic liver biopsies in 20 patients with documented acquired immunodeficiency syndrome (AIDS). Eighteen of 20 biopsies yielded abnormalities that could be related to diverse opportunistic infections and consisted of granulomatous and/or necrotizing lesions. However, prominent vascular lesions were observed in seven of these cases, with sinusoidal dilatations in two, peliosis hepatis in four, and angiosarcomatous changes in one.In the absence of a hepatic outflow obstruction, sinusoidal dilatations and peliosis hepatis are known to be associated with many hepatic and extrahepatic diseases.3 However, I speculate that the striking vascular changes found in these series could be directly