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August 19, 1992

The Biology of Developmental Dyslexia

Author Affiliations

From the Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Md.

JAMA. 1992;268(7):912-915. doi:10.1001/jama.1992.03490070094050

SELECTED CASE  A 30-year-old man was referred to the Child Psychiatry Branch of the National Institute of Mental Health for evaluation as a candidate for neuroimaging studies of developmental reading disorder, or dyslexia. Despite a master's degree and above-average intelligence, documented with the Wechsler Adult Intelligence Scale-Revised, his oral paragraph reading, as assessed with the Gray Oral Reading Test, fell between a second- and third-grade level, nearly 6 SEs below that expected on the basis of his verbal IQ.1 This placed his performance within a severely dyslexic range. Similarly, his spelling, which fell at a seventh-grade level (below the first percentile rank) on the Wide Range Achievement Test-Revised, was more than 5 SEs below expectation based on verbal and performance IQ and educational level.1Neurological examination was normal. Strong right-handedness was documented. Magnetic resonance imaging scans of the head were clinically normal, and a structured interview found no