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April 3, 1996

Pediatric Ibuprofen and Leukopenia

Author Affiliations

Boston University School of Medicine and Public Health Brookline, Mass

JAMA. 1996;275(13):986. doi:10.1001/jama.1996.03530370024017

To the Editor.  —Based on a large clinical trial of pediatric ibuprofen, we reported1 that hospital admission with a clinical diagnosis of "leukopenia" was more common among children treated with ibuprofen than among children treated with acetaminophen. This association was of borderline statistical significance (P=.04), and a causal relationship was not established. We now report results of a further analysis that includes white blood cell (WBC) count data for all hospitalized study participants.These data were obtained prospectively as part of the Boston University Fever Study; the methods and principal results have been described.1 Briefly, we conducted a practitioner-based, randomized, double-blind clinical trial to assess the safety of ibuprofen suspension for treatment of fever in children. The study included information on 83 915 children treated for febrile illnesses who received either acetaminophen (12 mg/kg) or ibuprofen in one of two dosages (5 or 10 mg/kg). Information was collected