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August 16, 1985

Diagnosis and Treatment of Streptococcal Pharyngitis

JAMA. 1985;254(7):907. doi:10.1001/jama.1985.03360070045006

To the Editor.—  Krober and colleagues' have added yet another convincing bit of evidence that the clinical course of streptococcal pharyngitis is altered by early antibiotic therapy. The closing paragraph of the accompanying editorial by Dr Fulginiti2 suggests that we should be "more liberal in the administration of penicillin" to individuals with a high likelihood of having streptococcal pharyngitis and that we "discontinue therapy in those patients who have negative cultures." I thoroughly agree with the first recommendation, but I question whether we should stop use of antibiotics in patients with negative cultures.