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September 23, 1992

Scientists 'Build a Better Mouse' to Trap Biochemical Secrets of Radiation-Resistant Cancer Cells

JAMA. 1992;268(12):1507-1512. doi:10.1001/jama.1992.03490120011004

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SOME SCIENTISTS appear to believe that if you build a better mouse the world will beat a path to your door.

Researchers at a number of centers are scurrying to use the latest genetic engineering techniques to create better mice for the study of human diseases and the development of effective therapies.

Scientists at the University of North Carolina at Chapel Hill just announced the creation of a mouse model for cystic fibrosis using advanced gene targeting techniques (Science. 1992;257:1083-1095). Others appear to be at various stages of success in making the mouse more like a human, at least in regard to diseases that plague our species.

Soon to be announced will be the development of a transgenic mouse that appears much more resistant to lethal levels of ionizing radiation. Researchers at the Uniformed Services University of the Health Sciences (USUHS), Bethesda, Md, are seeking a patent for a genetically