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August 16, 1985

Retinoic Acid Embryopathy: Timing of Exposure and Effects on Fetal Development

Author Affiliations

Child Evaluation Center University of Louisville School of Medicine

JAMA. 1985;254(7):909-910. doi:10.1001/jama.1985.03360070047015

To the Editor.—  Inadvertent use of isotretinoin (13-cis-retinoic acid), an oral synthetic vitamin A analogue, in the treatment of cystic acne in utero, has resulted in fetal wastage and congenital malformations primarily characterized by ear and eye anomalies, cardiac malformations including conotruncal lesions, and central ner