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August 16, 1985

Pemoline Abuse

Author Affiliations

From the Department of Psychiatry and Psychology, Mayo Clinic and Mayo Foundation, Rochester, Minn.

JAMA. 1985;254(7):946-947. doi:10.1001/jama.1985.03360070084028

Addictive use of the stimulant drug pemoline caused a delusional disorder in a middle-aged man. Discontinuance of use of the drug promptly reversed the psychosis, which subsequently recurred when pemoline was again used. Pemoline seems to be an addictive drug and has an additional property that heretofore has been attributed mainly to amphetamines— precipitation of a paranoid psychosis.

(JAMA 1985;254:946-947)