To the Editor.—
Shulman and colleagues1 describe a syndrome of autoimmune hemolytic anemia with both warm and cold autoantibodies. We, too, have followed up a patient with this syndrome who was initially seen at 47 years of age with hemolytic anemia, thrombocytopenia, and neutropenia.
Report of a Case.—
The patient demonstrated a direct antiplatelet antibody and a direct antineutrophil antibody. He had a positive direct Coombs' test for IgG and his indirect Coombs' test confirmed the presence of a warm-reacting antibody, but he also had a cold agglutinin titer of 1:16. His antinuclear antibody test results were negative, and he had no evidence of connective tissue disease at the time of the physical examination.The patient's condition improved dramatically on a regimen of high-dose steroids, the dose of which was then tapered. Over two months he maintained a mild compensated hemolysis. As his steroid regimen was reduced below 30 mg/day,
Nusbaum NJ, Khosla S. Autoimmune Hemolytic Anemia With Both Cold and Warm Autoantibodies. JAMA. 1985;254(9):1175-1176. doi:10.1001/jama.1985.03360090065019