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Article
October 11, 1985

Prognostic Importance of the White Blood Cell Count for Coronary, Cancer, and All-Cause Mortality

Author Affiliations

From the Multiple Risk Factor Intervention Trial Research Group, sponsored by the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md. Dr Ludwig was a Parker-Franas Research Foundation fellow during the analysis phase. Dr Grimm is an Established Investigator of the American Heart Association.

JAMA. 1985;254(14):1932-1937. doi:10.1001/jama.1985.03360140090031
Abstract

The relationship of white blood cell count (WBC) to fatal and nonfatal coronary heart disease (CHD) incidence and all-cause and cancer mortality was assessed in a subset of participants in the Multiple Risk Factor Intervention Trial (MRFIT). For this group of 6,222 middle aged men, total WBC count was found to be strongly and significantly related to risk of CHD, independent of smoking status. Change in WBC count from baseline to the annual examination just prior to the CHD event was found to be a significant and independent predictor of CHD risk. For each decrease in WBC count of 1,000/cu mm the risk for CHD death decreased 14%, controlling for baseline WBC count and other CHD risk factors (smoking, cholesterol level, diastolic blood pressure). The WBC count was strongly related cross-sectionally to cigarette smoking and smoking status as indicated by serum thiocyanate concentration. Smokers on average had a WBC count of 7,750/cu mm compared with 6,080/cu mm for nonsmokers. The WBC count was also significantly associated with cancer death, independent of reported smoking and serum thiocyanate levels.

(JAMA 1985;254:1932-1937)

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