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October 18, 1985

Pregnancy and Dysplastic Nevus Syndrome

JAMA. 1985;254(15):2063. doi:10.1001/jama.1985.03360150039014

To the Editor.—  When Sober,1 in his editorial entitled "The Changing Mole," summarizes the article by Foucar et al2 by stating "nevi in pregnant women do not appear to have premalignant or malignant changes developing with any great frequency," he ignores the exclusion of a significant group from the study. No patients in the study had dysplastic nevus syndrome (DNS).Ellis et al3 have demonstrated melanomas from patients with DNS to be markedly positive for estrogen and progesterone receptors. It is possible that the concern about pregnancy that has arisen because of anecdotal observations reflects the special problems and changes of nevi in pregnant women with DNS.I have one patient with DNS who during her pregnancy developed an explosive increase in number of nevi, changes in her nevi, and seven melanomas. My own terrifying anecdotal experience has given me a special concern for potential malignant changes during