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November 11, 1992

T-Lymphocyte Subsets in Intravenous Drug Users With HIV-1 Infection

Author Affiliations

San Giovanni Hospital
Latium Region Health Authority
Addolorata Hospital Rome, Italy

JAMA. 1992;268(18):2516-2517. doi:10.1001/jama.1992.03490180047019

To the Editor.  —Margolick et al1 recently reported a median change in CD4 cell count of 7.47/μL per 6 months among HIV-1 infected IVDUs. No significant difference in loss of CD4 cells over time was observed between active users and ex-users.Previous reports in the United States2 and in Italy3 had revealed much higher rates of CD4 cell loss in IVDUs.The Multicenter Prospective HIV Study of Rome is collecting information on over 4000 HIV-1 seropositive IVDUs for a longitudinal study of the natural history of HIV-1 infection. We have analyzed data from the San Giovanni Hospital subcohort where 734 HIV-1 seropositive subjects have been clinically and immunologically evaluated since 1985. Of these, 495 had injection of drugs as their chief risk behavior for HIV-1 infection. As of January 31, 1992, a total of 280 IVDUs (56.6%) had returned for at least one follow-up visit and had