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Article
November 25, 1992

Immunologic Aspects of Diseases of the Eye

JAMA. 1992;268(20):2869-2873. doi:10.1001/jama.1992.03490200121013
Abstract

A VARIETY of systemic immunologic conditions may affect the eye and its adnexal tissues. At times, ocular signs and symptoms may be the most striking and disabling aspects of immunologic disease. Several local conditions in which immunologic mechanisms are thought to play a significant role may also affect the eye. The major structures of the eye are illustrated in Fig 9-1. Immunologically mediated diseases of the cornea, the skin and mucous membranes, and the uveal tract and retina are discussed in this chapter.

DISEASES OF THE SKIN AND MUCOUS MEMBRANES OF THE EYE 

Allergic Conjunctivitis  Red, itchy, watery eyes are typical features of allergic rhinoconjunctivitis. This form of conjunctivitis, known simply as allergic conjunctivitis, results from the interaction of IgE on conjunctival mast cells with the pollen of airborne allergens. Preformed mediators, such as histamine, are released from mast-cell cytoplasmic granules, while arachidonic acid metabolites (prostaglandins and leukotrienes) are synthesized

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