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November 8, 1985

Immunoperoxidase in Fine-Needle Aspirate Specimens

Author Affiliations

Michigan State University Blodgett Memorial Medical Center, Butterworth and St Mary's Hospital Grand Rapids

JAMA. 1985;254(18):2553. doi:10.1001/jama.1985.03360180051010

To the Editor.—  I read with interest the article by Tell and associates1 regarding the clinical usefulness of the immunoperoxidase technique for prostate-specific antigen in the diagnosis of atypical metastasis from prostate cancer. This excellent article again brought to our attention the value of special histochemical techniques. I would only like to add that atypical metastasis from prostatic carcinoma may also be confirmed using immunoperoxidase techniques on cytological specimens obtained by fine-needle aspiration. Use of this technique was reported by Reifler and associates2 in a case of orbital metastasis. Nadji3 also demonstrated the possibilities of concurrent application of immunoperoxidase techniques with diagnostic cytology, including the establishment of a prostate carcinoma in a cervical lymph node. Certainly, fine-needle aspiration does not exclude the use of immunoperoxidase techniques and should be considered in selected cases, when an open biopsy would involve an extensive surgical procedure.