November 22, 1985

Is Remote Disease Associated With Candida Infection a Tomato?-Reply

Author Affiliations

Jackson, Tenn

JAMA. 1985;254(20):2891-2892. doi:10.1001/jama.1985.03360200041013

In Reply.—  Dr Turner asked for the "hidden truth" in my assertions. Here it is. As pointed out by Edwards,1 the observations of Iwata2 and colleagues' show that Candida albicans produces both high- and low-molecular weight toxins. The Iwata studies also show that these toxins affect both the immune system and the nervous system.Moreover, recent laboratory studies by Truss4 on patients with a wide range of endocrine and immune system disorders reveal metabolic abnormalities, including disturbances in fatty acids and amino acids. Truss has also published clinical observations describing patients with depression and many other systemic and nervous system symptoms who improved with antifungal therapy.5Rosenberg et al6 and Crutcher et al7 have also described the response— sometimes dramatic—of patients with psoriasis to oral nystatin, "an agent that was expected to work only on yeasts in the gut lumen." And Rosenberg et al6