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Article
December 9, 1992

Molecular Genetics and MedicineA Call for Papers

Author Affiliations

From the Institute for Molecular Genetics, Baylor College of Medicine, Houston, Tex (Dr Caskey); Division of Medical Genetics, Department of Medicine, University of Washington, Seattle (Dr Motulsky); and Department of Pathology, University of North Carolina School of Medicine, Chapel Hill (Dr McLendon).

JAMA. 1992;268(22):3241. doi:10.1001/jama.1992.03490220085034
Abstract

The year 1993 marks the 40th anniversary of the publication of the two short, seminal papers by Watson and Crick1,2 on the double helix structure of DNA. During these 40 years a revolution in biology and genetics has occurred as the insights gained from this discovery have moved these fields to a new molecular level of understanding. During the past decade we have also witnessed the beginning of another revolution in medical knowledge and therapeutics as the insights and techniques of molecular biology, molecular genetics, and recombinant DNA technology have begun to effect changes in the practice of medicine.

These advances in what is now being called molecular medicine are having an ever-increasing impact in many areas of medicine: (1) Molecular diagnostic techniques are moving diagnosis from the phenotypic to the genotypic level (eg, the sweat chloride test for cystic fibrosis vs the identification of a mutation in the

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