November 22, 1985

Minocycline-Associated Tooth Discoloration in Young Adults

Author Affiliations

From the Dermatology Branch (Drs Poliak, DiGiovanna, and Peck and Ms Gantt) and the Cancer Prevention Studies Branch (Dr Gross), National Cancer Institute, Bethesda, Md.

JAMA. 1985;254(20):2930-2932. doi:10.1001/jama.1985.03360200082032

After observing a patient with adult-onset tooth discoloration coincident with minocycline administration, we retrospectively surveyed a cohort of patients with severe cystic acne during therapeutic trials with isotretinoin. Four of 72 patients who had minocycline therapy during adolescence were found to have minocycline-associated tooth discoloration, which occurred in one case after only four weeks of treatment. Thus, minocycline must be considered as an uncommon cause of tooth staining in adults.

(JAMA 1985;254:2930-2932)