December 16, 1992

Invasive Haemophilus influenzae Infections in Men With HIV Infection

Author Affiliations

From the Epidemiology Program, Biomedical and Environmental Health Sciences, School of Public Health, University of California at Berkeley (Ms Steinhart and Dr Reingold); Bureau of Epidemiology and Disease Control, San Francisco (Calif) Department of Health (Dr Taylor and Ms Anderson); and Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Ga (Dr Wenger).

JAMA. 1992;268(23):3350-3352. doi:10.1001/jama.1992.03490230080032

Objective.  —To determine the incidence of invasive Haemophilus influenzae disease in men with the acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV) infection and the proportion of disease due to serotype b.

Design.  —Population-based, active surveillance.

Setting.  —San Francisco (Calif) Department of Health.

Participants.  —All men 20 to 49 years of age with invasive H influenzae disease.

Results.  —The cumulative incidences of invasive H influenzae disease in men 20 to 49 years of age with AIDS and in HIV-infected men 20 to 49 years of age without AIDS were 79.2 and 14.6 per 100000, respectively, but only 33% of cases were due to serotype b. The corresponding rates for invasive H influenzae b disease were 11.3 and 7.6 per 100000.

Conclusions.  —Men with AIDS or HIV infection are at increased risk of invasive H influenzae infections, including H influenzae b, but such infections are still infrequent in this population.(JAMA. 1992;268:3350-3352)