This report details the first case of cardiac xenotransplantation in a neonate. The recipient, a victim of hypoplastic left heart syndrome (HLHS), survived 20 days. Autopsy findings are documented. The cardiac graft showed only traces of cell-mediated rejection. Graft failure appears to have resulted from a progressive, potentially avoidable humoral response, unmodified by immunosuppression. Cardiac allotransplantation and selective baboon-to-human xenotransplantation deserve further exploration as investigational therapy for neonatal HLHS.
Bailey LL, Nehlsen-Cannarella SL, Concepcion W, Jolley WB. Baboon-to-Human Cardiac Xenotransplantation in a Neonate. JAMA. 1985;254(23):3321-3329. doi:10.1001/jama.1985.03360230053022