December 20, 1985

Baboon-to-Human Cardiac Xenotransplantation in a Neonate

Author Affiliations

From the Department of Surgery, Loma Linda University School of Medicine and Loma Linda University Medical Center, Loma Linda, Calif (Drs Bailey, Concepcion, and Jolley), and the Department of Pathology, Transplantation Immunology Laboratory), Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY (Dr Nehlsen-Cannarella). Dr Nehlsen-Cannarella is now with the Immunology Center, Loma Linda University Medical Center, Loma Linda, Calif.

JAMA. 1985;254(23):3321-3329. doi:10.1001/jama.1985.03360230053022

This report details the first case of cardiac xenotransplantation in a neonate. The recipient, a victim of hypoplastic left heart syndrome (HLHS), survived 20 days. Autopsy findings are documented. The cardiac graft showed only traces of cell-mediated rejection. Graft failure appears to have resulted from a progressive, potentially avoidable humoral response, unmodified by immunosuppression. Cardiac allotransplantation and selective baboon-to-human xenotransplantation deserve further exploration as investigational therapy for neonatal HLHS.

(JAMA 1985;254:3321-3329)