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March 28, 1986

Regulation of Animal Experimentation

Author Affiliations

Baylor College of Medicine Houston

JAMA. 1986;255(12):1567-1568. doi:10.1001/jama.1986.03370120041008

To the Editor.—  In their examination of animal research regulation, Overcast and Sales1 overlook the most significant regulatory development in recent years. The Public Health Service (PHS) has adopted a new funding policy, effective Dec 31, 1985, designed to strengthen the protection given to research animals.2 Institutions and investigators seeking financial support from PHS agencies will be governed by revised standards and procedures reflecting increased ethical concern for laboratory animals. Institutional committees must review the use of animals, and the new policy requires for the first time that review committees include at least one member unaffiliated with the institution and one nonscientist. Protocols must be evaluated against substantive principles set forth in the policy. Review committees are authorized to require modifications in, suspend, or withhold approval from research that fails to comply with the policy.One virtue of the PHS provisions is the authority they confer on review committees to