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March 28, 1986

Epidemiologic Support for Ethylene Oxide as a Cancer-Causing Agent

Author Affiliations

From the Section of Occupational Medicine, Research Department, National Board of Occupational Safety and Health, Solna, Sweden (Drs Hogstedt and Aringer and Ms Gustavsson), and the Department of Occupational Medicine, Karolinska Hospital, Stockholm (Dr Hogstedt).

JAMA. 1986;255(12):1575-1578. doi:10.1001/jama.1986.03370120053022

The mortality and incidence of cancer in three groups of workers with occupational exposure to ethylene oxide have been assessed. Eight cases of leukemia have occurred among 733 ethylene oxide—exposed workers compared with an expected 0.8 cases. Six cases of stomach cancer have been reported compared with 0.65 cases expected. These epidemiologic results provide support for an increased risk of malignancy in individuals with extended and intermittent exposure to low concentrations of ethylene oxide.

(JAMA 1986;255:1575-1578)