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April 18, 1986

DTP Vaccine-Reply

Author Affiliations

Surveillance, Investigations, and Research Branch
Division of Immunization Center for Prevention Services Centers for Disease Control Atlanta

JAMA. 1986;255(15):2026-2027. doi:10.1001/jama.1986.03370150068024

In Reply.—  In 1984, Barkin et al1 reported on a study of a reduced DTP vaccine dosage using half the recommended dose volume in a schedule of four doses at the usual recommended ages. They observed fewer febrile, local, and behavioral adverse events when compared with the recommended dose volume. These findings are supported by the observations of Baraff et al.2 Based on equivalent geometric mean pertussis agglutinin titers in the two groups at the time of the reinforcing dose (at 18 months of age) and also one month later, the authors concluded that protection might also be equivalent following a schedule of half of the recommended dose. Barkin and Samuelson state that these data are sufficient to suggest the use of reduced dosages as an alternative to the current policy; this would be for the purported reason of averting the fears of parents about more severe events