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June 19, 1996

Radiation Oncology

Author Affiliations

The University of Chicago, Chicago, Ill

JAMA. 1996;275(23):1852-1853. doi:10.1001/jama.1996.03530470080048

Three important aspects of radiation oncology are potentially important advances in cancer treatment. The first is a multidisciplinary therapeutic approach with important clinical application, the second is progress in the physics of radiation therapy that has clinical ramifications and for which there are recently published clinical results, and the third is an exciting laboratory study that soon will be translated to clinical practice.

In an attempt to develop a curative approach to locally advanced prostate cancer, a large cooperative group trial compared radiation therapy alone with radiation therapy and simultaneous androgen deprivation.1 In this study, patients with lesions too large for surgery but without evidence of distant metastases were randomly allocated to receive radiation therapy or total androgen blockade using a luteinizing hormone—releasing hormone agonist and an antiandrogen combined with radiation therapy. The treatment technique involved giving the hormone blockade for 2 months and then starting the radiation therapy