[Skip to Content]
[Skip to Content Landing]
May 9, 1986

Remitting Seronegative Symmetrical Synovitis With Pitting Edema

Author Affiliations

Temple University School of Medicine Episcopal Hospital Philadelphia

JAMA. 1986;255(18):2444. doi:10.1001/jama.1986.03370180070017

To the Editor.—  The article by McCarty et al1 is of interest. My purpose here is to call attention to a commonly occurring condition, namely, carpal tunnel syndrome, that may produce similar findings of edema of the hands and feet—for which a regimen of nonsteroidal and other drugs may be of limited or no benefit. Although various diseases are mentioned for consideration in evaluating these findings, carpal tunnel syndrome is ignored.A recent patient of mine, an 85-year-old man, was thought to have early seronegative rheumatoid arthritis. Instead, it proved to be bilateral carpal tunnel syndrome and his symptoms were completely relieved by conventional local therapy. In the article by McCarty et al, case 4 is stated to have nocturnal dysesthesiae in the median nerve distribution of both hands, which suggests similar entrapment. Carpal tunnel syndrome may, of course, occur alone or in combination with other diseases, including rheumatoid