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—We completely agree with the comments of Drs Caputo and Weitekamp. Oral metronidazole and vancomycin have equal efficacy in the treatment of mild to moderate C difficile colitis. The relative efficacy of each agent in patients with severe disease warrants further investigation.
Spera RV, Farber BF. The Treatment of Clostridium difficile Colitis-Reply. JAMA. 1993;269(16):2088. doi:10.1001/jama.1993.03500160054030