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May 12, 1993

Effect of Magnesium on Postoperative Dysrhythmias-Reply

Author Affiliations

Tufts University School of Medicine Boston, Mass
The Johns Hopkins University School of Medicine Baltimore, Md

JAMA. 1993;269(18):2370. doi:10.1001/jama.1993.03500180061034

In Reply.  —appreciate the opportunity to clarify the issues raised regarding our placebo-controlled, randomized trial of magnesium administration in cardiac surgery patients. Two other recent studies in cardiac surgery patients1-2 and another randomized trial3 of magnesium administration in patients with suspected acute myocardial infarction support the hypothesis that magnesium administration decreases morbidity and mortality in patients with ischemic cardiovascular disease.Regarding matching of treatment groups, Table 3 in our study accurately indicates that the treatment and placebo groups were matched with respect to the performance of coronary bypass grafting and/or valve replacement procedures. There were no significant differences between treatment groups in terms of the four patients who had electrode patches placed, an implantable defibrillator device placed, or a left ventricular aneurysm resection (in addition to coronary artery bypass grafting and/or valve replacement). Continuous electrocardiographic techniques were used to identify clinically important dysrhythmias while patients were