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Article
August 28, 1996

Estimating Exposure to Environmental Tobacco Smoke

Author Affiliations

RJ Reynolds Tobacco Company Winston-Salem, NC

JAMA. 1996;276(8):603. doi:10.1001/jama.1996.03540080025013
Abstract

To the Editor.  —Dr Pirkle and colleagues1 suggest that further research is needed to determine the health relevance of ETS exposures that result in serum cotinine concentrations of approximately 1 ng/mL. However, Pirkle et al fail to discuss that we reported data2-4 that show animals exposed to smoke repeatedly for 6 hours per day, with resultant mean cotinine concentrations at the end of the exposures up to 165 ng/mL, had effectively no toxicologic changes. Importantly, the particulate concentrations we used (up to 10 mg/m3) were large exaggerations of ETS concentrations (approximately 30 μ/m3) that have been reported in areas where smoking is allowed.5

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