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November 27, 1996

Hypofertility With Thick Cervical Mucus: Another Mild Form of Cystic Fibrosis?

Author Affiliations

Centre Hospitalier Régional de Lille Lille, France

JAMA. 1996;276(20):1638. doi:10.1001/jama.1996.03540200024023

To the Editor.  —Male infertility due to congenital bilateral absence of the vas deferens (CBAVD) is frequently recognized as a mild form of cystic fibrosis (CF).1,2 However, CF with primarily genital involvement may not be limited to males.

Report of a Case.  —We recently observed a 40-year-old woman with a medical history of infertility. She used oral contraceptives from 1974 to 1978. In 1975, she had electrocoagulation for ectropion. From 1981 to 1986, she had unprotected sexual intercourse but could not become pregnant. In 1986, she and her husband underwent investigations for infertility. Her husband's semen analysis was normal. Ovulation was confirmed by biphasic basal body temperature charts. Hysterosalpingogram was normal. The only consistent abnormality was found in postcoital tests. On 3 separate cycles, repetitive testing revealed tenacious mucus, which did not vary according to the time of cycle and contained no motile sperm. Testing for antisperm antibodies was