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January 1, 1997

New Routes to Goals of Prostate Cancer Research

JAMA. 1997;277(1):8-9. doi:10.1001/jama.1997.03540250016008

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AS 1997 gets under way, prostate cancer investigators are trying to narrow a search in a region of 80 to 300 or so genes on the long arm of chromosome 1. At the same time, many of these researchers are seeking to broaden prostate cancer research through a new teleconferencing network.

The chromosome searchers' goal is to pinpoint the location of a gene that, when it undergoes mutation, appears to increase a man's risk of developing a prostatic tumor in his 9th decade from about 15% to close to 90%. The telecommunicators' goal, in the words of Alan W. Partin, MD, PhD, Johns Hopkins Medical Institutions, Baltimore, Md, includes "addition of numerous sites around the country where prostate cancer research is being performed."

Chromosome Study  For the chromosome explorers, "strong evidence of a major prostate cancer susceptibility locus" (Science. 1996;274:1371-1374) is apparent from work at Johns Hopkins' Brady Urological Institute;