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February 19, 1997

The Multiple Risk Factor Intervention Trial (MRFIT)A Return to a Landmark Trial

Author Affiliations

From the Office of the Dean, Cornell University Medical College, New York, NY.

JAMA. 1997;277(7):595-597. doi:10.1001/jama.1997.03540310093041

In 1982 the results of the landmark Multiple Risk Factor Intervention Trial (MRFIT) were published in JAMA.1 MRFIT was a randomized primary prevention trial funded by the National Heart and Lung Institute (now the National Heart, Lung, and Blood Institute) to test whether multifactor intervention in 12 866 high-risk, asymptomatic middle-aged men would prevent fatal coronary heart disease (CHD) events compared with usual care. Minimum follow-up was 6 years.

MRFIT grew from the Task Force on Arteriosclerosis convened in 1970 by the National Heart and Lung Institute to devise a long-range strategy for preventing, treating, and controlling arteriosclerosis and its complications.2 The task force thoroughly reviewed data that had come from epidemiologic observations in the United States and abroad—including the findings of the Framingham Heart Study, the Seven Countries Study, and the Chicago Workers Study—and from clinical observations and smaller clinical trials linking risk factor modification