March 26, 1997

BRCA1 Mutations in Women With Ovarian Cancer-Reply

Author Affiliations

Chaim Sheba Medical Center Tel Hashomer, Israel

JAMA. 1997;277(12):963. doi:10.1001/jama.1997.03540360031019

In Reply.  —Our preliminary data related to the frequency of the 185delAG germline mutation in the BRCA1 gene in a subset of 79 of 585 Israeli women with ovarian cancer. Our study included 16 patients (20.3%) with borderline histopathology, none of whom carried the mutation. In subsequent extended analysis, 2 (5.6%) of 36 additional borderline cases were found to be mutation carriers (unpublished data). The latter finding is in line with the findings of 2.9% of mutation carriers having a positive family history among women with low malignant potential ovarian cancer (ie, presumably borderline) reported by Dr Shushan et al.1 Similarly, Rubin and coworkers2 reported that of 53 patients with ovarian cancer who might have been carriers of a variety of BRCA1 mutations, 3 were of a low malignant potential type.These data indeed support the notion that the genetics of borderline ovarian tumors differ from that of the invasive