Gastric infection with Helicobacter pylori is common throughout the world. Usually acquired in childhood, this infection causes a chronic active gastritis. Chronic infection is usually asymptomatic, but its presence predisposes infected individuals to peptic ulcer disease.1 Unlike gastropathies associated with nonsteroidal anti-inflammatory drugs (NSAIDs) or alcohol, which are erosive and hemorrhagic, H pylori gastritis is nonerosive and nonhemorrhagic,2 the pathology of which is not visible through an endoscope. Thus, H pylori gastritis would not be considered a satisfactory explanation for chronic gastrointestinal blood loss or iron deficiency. However, in this issue, Yip et al3 report in a cross-sectional study of Alaskan Yupik Eskimos (Yupiks) a high prevalence of
See also p 1135.
erosive-hemorrhagic gastritis, gastrointestinal bleeding, iron deficiency, and gastric H pylori infection. Is erosive-hemorrhagic gastritis with chronic gastric bleeding leading to iron deficiency another consequence of chronic H pylori infection? If so, is this manifestation unique
Wood H, Feldman M. Helicobacter pylori and Iron Deficiency. JAMA. 1997;277(14):1166-1167. doi:10.1001/jama.1997.03540380080037