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April 16, 1997

Bioequivalence of Levothyroxine Preparations: Industry Sponsorship and Academic Freedom-Reply

Author Affiliations

University of California, San Francisco
Thomas Jefferson University Philadelphia, Pa
Washington State University Spokane
San Mateo County General Hospital San Mateo, Calif

JAMA. 1997;277(15):1200-1201. doi:10.1001/jama.1997.03540390030022

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In Reply.  —We appreciate the comments by Mr Eckert to clarify and defend Knoll's action to date, although some of the study chronology is in error. We are delighted at the prospect of finally being able to publish our findings. We have tried our best to cooperate with Knoll even though we believed their concerns to be unjustified. We found it impossible to comply with many of their requests because to do so would have intentionally altered our study findings.We are pleased that Knoll now recognizes the importance of academic freedom, the peer review process, and the need to allow scientific debate to occur.This unfortunate incident has illuminated the fragile relationship that could exist between a sponsor and investigators when the results of a study are not as anticipated. The difficult, sobering, and painful lessons learned should be remembered by all when collaborations between industry and academia occur. We know