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August 20, 1997

Transmission of HIV Possibly Associated With Exposure of Mucous Membrane to Contaminated Blood

JAMA. 1997;278(7):539-541. doi:10.1001/jama.1997.03550070031017

IN FEBRUARY 1996, transmission of human immunodeficiency virus (HIV) by an unknown route involving an HIV-infected man and his previously uninfected female sex partner was reported to CDC. This report summarizes the epidemiologic investigation of this transmission, which suggests that the woman was infected through mucous membrane exposure to contaminated blood.*

In 1992, after obtaining informed consent from the HIV-infected man and his uninfected female sex partner, they were enrolled in a study in which couples with one HIV-infected partner and one non-HIV-infected partner were extensively counseled, administered questionnaires, and tested periodically for HIV infection. Blood drawn from the woman on July 19, 1994, was HIV-negative by both enzyme immunoassay (EIA) and polymerase chain reaction (PCR). However, serum specimens obtained from the woman on July 24, 1995, and September 11, 1995, were positive by both EIA and immunofluorescent assay. During the interval from the month before her last HIV-negative test