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August 20, 1997

The Molecular and Genetic Basis of Neurological Disease

Author Affiliations

University of Michigan Ann Arbor


edited by Roger N. Rosenberg, Stanley B. Prusiner, Salvatore DiMauro, and Robert L. Barchi, 2nd ed, 1430 pp, with illus, $250, ISBN 0- 7506-9668-0, Woburn, Mass, Butterworth-Heinemann, 1997.

JAMA. 1997;278(7):599. doi:10.1001/jama.1997.03550070091049

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This is a successful revision of a multiauthor text designed to serve as a reference on neurogenetic disorders and the molecular basis of neurologic diseases. The editors have done an excellent job of assembling a collection of expert authors, and the quality of individual chapters is high.

The majority of chapters are devoted to monogenic entities and summarize succinctly the clinical features, biochemistry, and genetics of the disorders under discussion. In the great majority of these chapters, the quality of writing is excellent, and the reference lists are extensive. These chapters are valuable reviews of their topics and are the core of the book. A number of chapters move beyond discussion of monogenic disorders. There are excellent sections on mitochondrial disorders and prion diseases. Some effort is made to discuss the genetic and molecular basis of common disorders such as Alzheimer disease, schizophrenia, mood disorders, alcoholism, and multiple sclerosis. These