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—More than 100 potential risk factors for CHD have been reported. My article focused on 17 promising new risk factors that have therapeutic implications. I agree with Drs Stetson and Schrodt that psychosocial risk factors are promising as is the association of OSA with cardiovascular disease risk as outlined by Dr Davidson. However, the status of these candidate risk factors is not as advanced in establishing either the independence of other factors or the therapeutic efficacy of risk factor modulation on the development of coronary artery disease.Whether the statistically significant changes in the homocysteine concentrations that Dr DeRose and colleagues have observed with lifestyle alterations are physiologically meaningful requires further study.
Hoeg JM. Expanding and Understanding Risk Factors for Coronary Heart Disease-Reply. JAMA. 1997;278(8):636. doi:10.1001/jama.1997.03550080046036