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Article
June 28, 1884

Vaccination as a Preventive of Hydrophobia and Yellow Fever.

JAMA. 1884;II(26):719. doi:10.1001/jama.1884.02390490019006

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Abstract

—While M. Pasteur claims to have more than twenty dogs which he has rendered no longer susceptible to attacks of hydrophobia by inoculating them with the virus of that disease, after it had been attenuated or diluted by passing through several monkeys and rabbits; Dr. Domingo Freire, of Rio Janeiro, claims to have discovered the specific virus of yellow fever, and after inoculating some of the lower animals with it, he had used the diluted virus for vaccinating several hundred persons, and rendering them unsusceptible to the fever. Dr. Freire represents the specific virus or cause of yellow fever to be a vegetable parasite, which he has named cryptococcus xanthogenius. By what processes his discovery was made we are not yet informed; neither have we sufficient knowledge of the tests to which the 400 inoculated persons have been subjected, to establish our faith in the reliability of the claims, so

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