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On October 11, 1884, M. Brown-Séquard reported to the Société de Biologie, that he had concluded from a number of experiments that asphyxia depends only on the inhibiting power of carbonic acid over the excito-motor function of the respiratory centres. On October 18, however, M. Bert replied to this statement, and asserted that he believed that the true cause of the convulsions in asphyxia is the deprivation of oxygen; this opinion was founded upon the fact that convulsions ensue when animals are deprived of oxygen, and when there is no variation in the amount of the carbonic acid; and furthermore, they do not appear when there is an accumulation in the organism of toxic doses of the acid. If the acid be an excitant of the nervous centres the effects should ensue when there is a slow accumulation; which is not the case. He thought it certain that the phenomena
THE ROLE OF CARBONIC ACID IN ASPHYXIA.. JAMA. 1885;IV(20):547. doi:10.1001/jama.1885.02390950015006