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Article
March 6, 1886

ACTION OF SUBCUTANEOUS INJECTIONS OF COCAINE.

JAMA. 1886;VI(10):278. doi:10.1001/jama.1886.04250030026014

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Abstract

To the Editor of the Journal: 

Dear Sir:  —With the view of contributing to the knowledge of the action of subcutaneous injections of cocaine, I beg leave to submit the following observations made upon myself:Having read so much of the exhilarating and enlivening actions of cocaine and of its great stimulating power upon the cerebral nervous system, I resolved to try its effects upon myself. For this purpose I administered to myself, being in good health and of usual normal spirits and mental disposition, a subcutaneous injection of ½ grain of muriate of cocaine (Merck), repeating the dose after five minutes, as no effect whatever had taken place in the interval. About five minutes after the last injection I felt slight dizziness in the head, a prickling sensation in the tips of my fingers, and slight pressure in the epigastrium—all of which symptoms passed off within ten minutes. I

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