The average length of time, I believe, required for a subcutaneous injection of morphia to take effect as an anodyne is about fifteen minutes; for the hypnotic effect a still longer time is required. The following case is interesting on account of the facts that the drug acted in a remarkably short time, and that at times there was no appreciable interval between the anodyne and hypnotic effects; and on account of the favorable action of quinine in a case of sciatica.
On March 13, at 8 p. m., I was called to see A. F. H., æt. 54, who who was suffering from a severe attack of sciatica on the right side. For sufficient reasons I administered morphia, gr. 1/6, with gr. 1/200 of atropia. As usual when I administer any drug subcutaneously I noticed the time. While replacing my syringe in the case the patient threw his arms
EGGLESTON WG. QUININE IN SCIATICA—UNUSUAL SUSCEPTIBILITY TO MORPHIA, WITH TOLERANCE OF THE DRUG.. JAMA. 1886;VI(15):398-399. doi:10.1001/jama.1886.04250040034003