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—The remarkable case of irascibility or mental disorder from tobacco, reported by Dr. Batten, is not so exceptional as it seems, for I know a similar instance in which the fumes of tobacco irritated the brain and mind to such a degree that the afflicted gentleman is so forcibly impelled to assault the offending smoker as to require a very decided effort on his part to resist the impulse thereto. Many a time he has prevented himself from doing so only by hastily turning and going away from the transgressor. Indeed, for the time being, he feels like killing the smoking offender, a lamentable state of mind to be artificially induced by an extraneous toxic agent, especially one in such common use as tobacco. Nothing else affects him so but tobacco, hence he is obliged to keep away from those who smoke altogether, which is a very difficult
Ziegler GJ. THE TOBACCO POISON.. JAMA. 1887;IX(17):542. doi:10.1001/jama.1887.02400160030009