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The action of drugs on the circulation and secretion of the kidney is a subject as interesting as it is comparatively little known. A brief and valuable contribution to the subject was made by Dr. C. D. F. Phillips, of London, to the Ninth International Medical Congress, and published in the Lancet, of November 12, 1887. The experiments were made on cats and dogs. The results arrived at may be summarized as follows:
The effects of caffeine citrate, in half-grain doses: The blood-pressure is first lowered, and is then raised, both effects being of short duration and slight, especially the rise of pressure. The heart showed first a diminution in the force of the beats, followed by a slowing, with beats of markedly increased force. On the kidney caffeine causes at first contraction, lasting two or three minutes, and accompanied by diminution or even arrest of secretion; this is followed
THE ACTION OF DRUGS ON THE KIDNEY.. JAMA. 1887;IX(25):786–787. doi:10.1001/jama.1887.02400240018004