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February 29, 1908


Author Affiliations


JAMA. 1908;L(9):687-688. doi:10.1001/jama.1908.25310350033003

Last summer von Pirquet reported that vaccination of tuberculous individuals with old tuberculin gave rise to a typical local reaction. Since then several observers have reported on this reaction, some favorably, others more or less unfavorably.

My series of cases includes infants from 3 months to 4 years of age (55 cases), children at an orphans' home from 5 to 14 years of age (51), persons seen in dispensary and private practice, youngest 9 years, oldest 51 years (32), and twelve cases of advanced lung tuberculosis in men.

For the vaccination, use was made of Koch's old tuberculin, diluted with one-half of 1 per cent. carbolic acid to 25 per cent. The solution kept for a long time, and the carbolic acid did not cause any skin reaction when tried alone. Instead of von Pirquet's special chisel-like vaccination lance, one was made by filing off the point of a blood

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